Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.

Updated: 2017 Aug. 1

| Home | Kinexus | Contact | Credits

Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: MED1 All Species: 24.24
Human Site: S227 Identified Species: 48.48
UniProt: Q15648 Number Species: 11
    Phosphosite Substitution
    Charge Score: 0.18
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q15648 NP_004765.2 1581 168478 S227 M N L K Y Y V S P S D L L D D
Chimpanzee Pan troglodytes XP_001172395 1581 168474 S227 M N L K Y Y V S P S D L L D D
Rhesus Macaque Macaca mulatta
Dog Lupus familis XP_537654 1583 168625 S227 M N L K Y Y A S P S D L L D D
Cat Felis silvestris
Mouse Mus musculus Q925J9 1575 167122 S227 M N M K Y Y A S P S D L L D D
Rat Rattus norvegicus NP_001127833 1567 166392 D215 K Y Y A S P S D L L H D T T A
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001521297 422 46589
Chicken Gallus gallus XP_418125 1594 169410 S239 M N L K Y Y V S P Y D L F E D
Frog Xenopus laevis Q6INP8 1570 165663 D215 K Y Y V S P Y D L F D D G T G
Zebra Danio Brachydanio rerio XP_700209 1694 176982 S214 V S L Q C Y V S P N D I F E E
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9VP05 1475 149513 V165 G D F A D F T V Q L E G L S S
Honey Bee Apis mellifera XP_395879 1811 193227 G232 I L E R R R G G H A M K L T Y
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_786427 2421 258175 S247 M R L T Y F V S P Y D L L D V
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.9 N.A. 98 N.A. 94.4 93.9 N.A. 24.4 87.6 72.5 56.4 N.A. 22 24.4 N.A. 25.7
Protein Similarity: 100 100 N.A. 98.9 N.A. 97.1 96.5 N.A. 25.7 93.5 81.7 69 N.A. 38.9 41.1 N.A. 38.5
P-Site Identity: 100 100 N.A. 93.3 N.A. 86.6 0 N.A. 0 80 6.6 40 N.A. 6.6 6.6 N.A. 66.6
P-Site Similarity: 100 100 N.A. 93.3 N.A. 93.3 0 N.A. 0 86.6 6.6 86.6 N.A. 26.6 26.6 N.A. 73.3
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 17 0 0 17 0 0 9 0 0 0 0 9 % A
% Cys: 0 0 0 0 9 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 9 0 0 9 0 0 17 0 0 67 17 0 42 42 % D
% Glu: 0 0 9 0 0 0 0 0 0 0 9 0 0 17 9 % E
% Phe: 0 0 9 0 0 17 0 0 0 9 0 0 17 0 0 % F
% Gly: 9 0 0 0 0 0 9 9 0 0 0 9 9 0 9 % G
% His: 0 0 0 0 0 0 0 0 9 0 9 0 0 0 0 % H
% Ile: 9 0 0 0 0 0 0 0 0 0 0 9 0 0 0 % I
% Lys: 17 0 0 42 0 0 0 0 0 0 0 9 0 0 0 % K
% Leu: 0 9 50 0 0 0 0 0 17 17 0 50 59 0 0 % L
% Met: 50 0 9 0 0 0 0 0 0 0 9 0 0 0 0 % M
% Asn: 0 42 0 0 0 0 0 0 0 9 0 0 0 0 0 % N
% Pro: 0 0 0 0 0 17 0 0 59 0 0 0 0 0 0 % P
% Gln: 0 0 0 9 0 0 0 0 9 0 0 0 0 0 0 % Q
% Arg: 0 9 0 9 9 9 0 0 0 0 0 0 0 0 0 % R
% Ser: 0 9 0 0 17 0 9 59 0 34 0 0 0 9 9 % S
% Thr: 0 0 0 9 0 0 9 0 0 0 0 0 9 25 0 % T
% Val: 9 0 0 9 0 0 42 9 0 0 0 0 0 0 9 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 17 17 0 50 50 9 0 0 17 0 0 0 0 9 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _